Scientists get a peek into how some fish change sex

All About Animals

In this photo provided by Kevin Bryant, a dominant male bluehead wrasse, upper left, defends its spawning territory and a group of females, yellow, off the coast of Florida. Normally the male and females stay as they are, feeding together and occasionally mating. But if a predator happens to snatch up the lead male, the dominant female in the group will take up rank _ by becoming a male. (Kevin Bryant via AP)

NEW YORK (AP) — For nearly 500 fish species, the great divide between sexes is more like a murky line: If circumstances call for it, the fish can swap their sex, with females turning into males in some species and males turning into females in others.

Biologist Erica Todd from the University of Otago in New Zealand says that people think of sex as being fixed, “but there are so many fish that can push it in the other direction.”

For decades scientists have known about the sex trades, but they have had limited understanding of how the exchange happens. In a study published Wednesday in Science Advances, Todd and her colleagues detail the molecular events behind this ability, as well as what keeps mammals stuck as one sex or another.

The bluehead wrasse was researched in the study, a reef fish that swims in small groups with a dominant blue-headed male and a posse of smaller yellow females. The male and females stay as they are normally, feeding together and occasionally mating. However, if a predator happens to snatch up the lead male, the dominant female in the group will transform into a male.

“The sex change in this species is remarkable because it is so quick,” Todd said. It takes only minutes to a few hours for the behavior of the female’s to become more territorial and aggressive like a male. Within a few days, she courts other females. And after eight to 10 days, she is fully transitioned to a male.

The research team removed the lead males from several wrasse groups in the Florida Keys. As the females changed sexes, the researchers took DNA from cells in the animal’s brains and genitals so they could follow what was happening at the genetic level.

Removing the males likely stressed the females. The hormones released from that stress dial back the activity of the gene that makes the female hormone estrogen, and eventually ovary cells start to die. At the same time, those hormones increase activity in the genes that produce male hormones, and later testicles form.

At a certain point, the reproductive gland “is mostly dying female cells and proliferation of early male cells,” Todd said.

Hormones were not the only thing switching around, however. The scientists also saw a complete rearrangement of chemical tags that attach to DNA. These tags turn genes on or off and have specific arrangements in males and females.

As the female fish transitioned to a male, these tags were removed and reorganized, almost as if the fish was being reprogrammed.

“They are sort of poised and ready to go either direction” like a seesaw, she said. The hormones help push it to the male side.

Matthew Grober, from Georgia State University, was skeptical of the findings, especially of the results that stress is the source that triggers the change. He questioned how the fish avoid changing sex from day-to-day stress and suspects something else is at play.

All animals with a backbone, including humans, share these genes, raising the question of whether all of them have a deep-seated capability to switch sex.

Todd says that this is unlikely. A human’s reproductive systems are more complex and would be far more complicated to rewire. There is also cell machinery that aggressively opposes the seesaw from swinging the other way.

“These fish are just able to go back and remove that suppression,” she said.

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