It happened at the intersection of Live Oak and South Bishop at 8:30 Tuesday morning.
The 17-year-old driver of the 2002 Nissan Maxima -- who is a varsity player -- was treated and released at Shannon. The other three junior varsity players were taken to hospitals with non-life threatening injuries.
According to reports, the car collided with a tree.
School administration officials would not comment on the accident, other than to say they were concerned about the students.